What Is NAD+?
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme present in every living cell. It is essential to the function of the mitochondria — the energy-producing organelles in your cells — and plays a central role in over 500 enzymatic reactions, including those governing DNA repair, gene expression, and cellular signaling.
NAD+ levels decline significantly with age — by as much as 50% between the ages of 40 and 60 — contributing to reduced cellular energy, accelerated aging, cognitive decline, and metabolic dysfunction. IV administration bypasses gastrointestinal absorption barriers, delivering NAD+ directly to the bloodstream at concentrations unachievable through oral supplementation.
How It Works
NAD+ serves as a substrate for sirtuins (longevity-related enzymes), poly ADP-ribose polymerases (PARPs, which govern DNA repair), and CD38 (an enzyme involved in immune function and calcium signaling). When NAD+ levels are restored to optimal ranges, these pathways activate, supporting:
- Enhanced mitochondrial biogenesis and energy output
- Accelerated DNA damage repair
- Improved insulin sensitivity and metabolic efficiency
- Modulation of inflammatory pathways
- Neurological resilience and neuroprotection
The Infusion Experience
NAD+ infusions at The FMR are administered in a private clinical setting under physician supervision. A typical session runs 2–4 hours depending on dose. Most patients report a warm, energizing sensation during infusion, with cognitive clarity and improved energy beginning within 24–48 hours.
In-home IV delivery is available for maintenance sessions following the initial induction course, administered by licensed medical professionals.
Protocol Details
Induction protocol: 3–5 infusions over 7–14 days, at doses ranging from 250 mg to 1,000 mg per session, titrated to patient tolerance and clinical goals. Induction establishes a therapeutic baseline and allows your physician to assess your response.
Maintenance protocol: Once-monthly infusions to sustain optimal NAD+ levels. Some patients combine monthly IV infusions with NAD+ precursor supplementation (NMN or NR) between sessions for continuous support.
Dosing is always individualized. Patients with specific goals — cognitive performance, metabolic optimization, or longevity — may follow different protocols from those seeking fatigue reduction or recovery support.
What to Expect
During infusion, patients commonly experience a mild flushing sensation, a feeling of warmth, and occasional transient nausea at higher doses — all of which are managed by adjusting infusion rate. Most patients describe the overall experience as deeply relaxing.
Post-infusion, patients frequently report sharper mental clarity, elevated mood, and improved energy within the first 24–48 hours. Full benefit of the induction course typically becomes apparent within 1–2 weeks of completing the initial series.
Safety & Physician Oversight
All NAD+ infusions at The FMR are administered under physician supervision by licensed clinical staff. Pre-infusion assessment includes medical history review and, where indicated, metabolic and renal function labs to ensure appropriate candidacy.
NAD+ IV therapy has a well-established safety profile at therapeutic doses. Side effects are generally mild and infusion-rate dependent. We do not administer NAD+ at maximum doses without first establishing patient tolerance through a titrated induction.
Frequently Asked Questions
Why IV instead of oral NAD+ supplements?
Oral NAD+ precursors (NMN, NR) require conversion through metabolic pathways and are subject to significant gastrointestinal breakdown. IV delivery bypasses these limitations entirely, achieving plasma concentrations 10–100x higher than oral supplementation — and producing effects within hours rather than weeks.
How long does each infusion take?
Infusion time depends on dose and rate. Most sessions at The FMR run between 2 and 4 hours. Our clinical team titrates the rate to your comfort and tolerance, particularly during the induction series.
Can I combine NAD+ with other IV protocols?
Yes. NAD+ pairs well with glutathione pushes, Vitamin C, B-complex, and magnesium. Combination protocols are designed by your physician. Some patients follow their NAD+ infusion with an IV vitamin push on the same visit.
Is NAD+ available for in-home delivery?
Yes. In-home NAD+ infusions are available for maintenance protocols following the initial in-clinic induction series. Our licensed medical team brings the full clinical experience to you.
How often should I get NAD+ infusions?
After the induction series, most patients maintain optimal levels with one infusion per month. High-performance patients or those in active longevity protocols may opt for bi-weekly maintenance. Your physician will recommend a frequency based on your goals and clinical response.