What Is NAD+?
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme present in every living cell. It is essential to the function of the mitochondria — the energy-producing organelles in your cells — and plays a central role in over 500 enzymatic reactions, including those governing DNA repair, gene expression, and cellular signaling.
NAD+ levels decline significantly with age — by as much as 50% between the ages of 40 and 60 — contributing to reduced cellular energy, accelerated aging, cognitive decline, and metabolic dysfunction. IV administration bypasses gastrointestinal absorption barriers, delivering NAD+ directly to the bloodstream at concentrations unachievable through oral supplementation.
How It Works
NAD+ serves as a substrate for sirtuins (longevity-related enzymes), poly ADP-ribose polymerases (PARPs, which govern DNA repair), and CD38 (an enzyme involved in immune function and calcium signaling). When NAD+ levels are restored to optimal ranges, these pathways activate, supporting:
- Enhanced mitochondrial biogenesis and energy output
- Accelerated DNA damage repair
- Improved insulin sensitivity and metabolic efficiency
- Modulation of inflammatory pathways
- Neurological resilience and neuroprotection
The Infusion Experience
NAD+ infusions at The FMR are administered in a private clinical setting under physician supervision. Most patients report a warm, energizing sensation during infusion, with cognitive clarity and improved energy beginning in the hours and days that follow.
In-home IV delivery is available for maintenance sessions following the initial induction course, administered by licensed medical professionals.
Protocol Details
NAD+ therapy at The FMR follows an induction phase to establish a therapeutic baseline, followed by a maintenance phase tailored to your clinical picture and goals. Some patients pair maintenance infusions with NAD+ precursor supplementation between sessions for continuous support.
Exact formulation, dosing, and frequency are determined during your physician consultation based on your clinical picture and goals.
What to Expect
During infusion, patients commonly experience a mild flushing sensation, a feeling of warmth, and occasional transient nausea at higher doses — all of which are managed by adjusting infusion rate. Most patients describe the overall experience as deeply relaxing.
Post-infusion, patients frequently report sharper mental clarity, elevated mood, and improved energy in the days that follow. Full benefit of the induction course typically becomes apparent in the weeks after completing the initial series.
Safety & Physician Oversight
All NAD+ infusions at The FMR are administered under physician supervision by licensed clinical staff. Pre-infusion assessment includes medical history review and, where indicated, metabolic and renal function labs to ensure appropriate candidacy.
NAD+ IV therapy has a well-established safety profile at therapeutic doses. Side effects are generally mild and infusion-rate dependent. We do not administer NAD+ at maximum doses without first establishing patient tolerance through a titrated induction.
Frequently Asked Questions
Why IV instead of oral NAD+ supplements?
Oral NAD+ precursors (NMN, NR) require conversion through metabolic pathways and are subject to significant gastrointestinal breakdown. IV delivery bypasses these limitations, achieving therapeutic plasma concentrations and producing effects on a far shorter timeline than oral supplementation.
How long does each infusion take?
Session length varies with the protocol your physician designs for you. Our clinical team titrates the infusion rate to your comfort and tolerance, particularly during the induction series.
Can I combine NAD+ with other IV protocols?
Yes. NAD+ pairs well with glutathione pushes, Vitamin C, B-complex, and magnesium. Combination protocols are designed by your physician.
Is NAD+ available for in-home delivery?
Yes. In-home NAD+ infusions are available for maintenance protocols following the initial in-clinic induction series. Our licensed medical team brings the full clinical experience to you.
How often should I get NAD+ infusions?
Frequency is individualized. Your physician will recommend a rhythm based on your goals, clinical response, and tolerance — ranging from intensive induction in the early phase to spaced maintenance thereafter.